PE-22-28
Research PeptideAlso known as: Spadin analog
What is PE-22-28?
PE-22-28 is a synthetic peptide derived from spadin with potential antidepressant and neurogenic properties.
How It Works
PE-22-28 blocks TREK-1 potassium channels, potentially enhancing serotonergic neurotransmission and promoting neurogenesis.
What Research Shows
Key Findings:
- Rapid antidepressant effects in animal models
- May promote hippocampal neurogenesis
- Novel mechanism of action
Limited Human Research
Most research on PE-22-28 has been conducted in animal models. Human clinical trials are limited or absent. Results may not translate directly to humans.
Dosing Protocol
These are general guidelines based on research literature and community protocols. Individual dosing should be determined by a qualified healthcare provider.
Safety & Risks
Reported Side Effects:
Contraindications:
- Pregnancy
- Seizure disorders (theoretical)
Important: This information is for research purposes only. Always consult with a qualified healthcare provider before using any peptide. Never use peptides without proper medical supervision.
Sourcing & Quality
Quality varies significantly between peptide sources. When sourcing PE-22-28, consider:
- Third-party testing (HPLC, Mass Spectrometry)
- Certificate of Analysis (CoA) availability
- Purity levels (>98% recommended)
- Beware of LPS (endotoxin) contamination
CalcPep does not sell peptides or recommend specific vendors. Always verify product quality through independent testing.
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