CalcPep Research
Comparison

Semaglutide vs Tirzepatide: Comparing GLP-1 Weight Loss Medications

Both are FDA-approved GLP-1 medications for weight loss and diabetes. Tirzepatide is a newer dual-agonist (GIP/GLP-1) showing greater weight loss in trials, while Semaglutide has more long-term safety data.

Semaglutide
Typical Dose: 0.25-2.4 mg
Frequency: Once weekly
Route: Subcutaneous injection
FDA Approved: Yes
View Semaglutide Details
Tirzepatide
Typical Dose: 2.5-15 mg
Frequency: Once weekly
Route: Subcutaneous injection
FDA Approved: Yes
View Tirzepatide Details
Key Differences
AspectSemaglutideTirzepatide
MechanismGLP-1 receptor agonist onlyDual GIP + GLP-1 receptor agonist
Weight Loss15-17% in trialsUp to 22.5% in trials
Dosing0.25-2.4 mg weekly2.5-15 mg weekly
FDA StatusApproved since 2017 (diabetes), 2021 (weight)Approved since 2022 (diabetes), 2023 (weight)
FormsInjectable and oral (Rybelsus)Injectable only
When to Use Each

Semaglutide May Be Better For:

  • When long-term safety data is priority
  • Cardiovascular risk reduction focus
  • Insurance coverage considerations
  • Oral option preferred (Rybelsus)

Tirzepatide May Be Better For:

  • Maximum weight loss is goal
  • Superior A1C reduction needed
  • GLP-1 alone insufficient
  • Better GI tolerance (some patients)

Both Are Good For:

Type 2 diabetes managementChronic weight managementMetabolic syndromeCardiovascular risk reduction
Side Effects Comparison

Semaglutide

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Injection site reactions

Tirzepatide

  • Nausea
  • Diarrhea
  • Decreased appetite
  • Vomiting
  • Constipation
The Verdict

Tirzepatide shows superior weight loss results in head-to-head trials. However, Semaglutide has more long-term safety data and an oral option. Both are effective; choice often depends on insurance, availability, and individual response.

Research Data

Semaglutide

100
Animal Studies
50
Human Studies

Tirzepatide

50
Animal Studies
30
Human Studies
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Research Purposes Only

This comparison is for educational purposes. Consult a healthcare provider before using any peptides.