CalcPep Research
Comparison

Retatrutide vs Tirzepatide: Triple vs Dual Agonist Comparison

Retatrutide is an investigational triple agonist (GIP/GLP-1/glucagon) showing even greater weight loss than Tirzepatide in trials. However, it is not yet FDA-approved, while Tirzepatide is available now.

Retatrutide
Typical Dose: 1-12 mg
Frequency: Once weekly
Route: Subcutaneous injection
FDA Approved: No
View Retatrutide Details
Tirzepatide
Typical Dose: 2.5-15 mg
Frequency: Once weekly
Route: Subcutaneous injection
FDA Approved: Yes
View Tirzepatide Details
Key Differences
AspectRetatrutideTirzepatide
MechanismTriple agonist: GIP + GLP-1 + GlucagonDual agonist: GIP + GLP-1
Weight LossUp to 24% in trialsUp to 22.5% in trials
FDA StatusInvestigational (Phase 3)FDA-approved
AvailabilityClinical trials only (research peptides exist)Commercially available
Energy ExpenditureMay increase via glucagon componentMinimal effect on energy expenditure
When to Use Each

Retatrutide May Be Better For:

  • Maximum possible weight loss
  • Research/clinical trial settings
  • When dual agonists insufficient
  • Future consideration (pending approval)

Tirzepatide May Be Better For:

  • FDA-approved option needed now
  • Established safety profile
  • Insurance coverage available
  • Type 2 diabetes indication

Both Are Good For:

Significant weight loss goalsMetabolic health improvementAppetite suppression
Side Effects Comparison

Retatrutide

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation

Tirzepatide

  • Nausea
  • Diarrhea
  • Decreased appetite
  • Vomiting
  • Constipation
The Verdict

Tirzepatide is the clear choice for those needing an FDA-approved medication now. Retatrutide shows promise for even greater efficacy but is not yet approved. Those interested should watch for FDA approval timeline.

Research Data

Retatrutide

20
Animal Studies
5
Human Studies

Tirzepatide

50
Animal Studies
30
Human Studies
Dosing Tools
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Research Purposes Only

This comparison is for educational purposes. Consult a healthcare provider before using any peptides.