CalcPep Research
Comparison

Ipamorelin vs GHRP-6: Comparing Growth Hormone Secretagogues

Both are growth hormone releasing peptides (GHRPs) that stimulate GH release via ghrelin receptors. Ipamorelin is more selective with fewer side effects, while GHRP-6 is more potent but increases appetite and cortisol.

Ipamorelin
Typical Dose: 200-300 mcg
Frequency: 2-3 times daily
Route: Subcutaneous injection
FDA Approved: No
View Ipamorelin Details
GHRP-6
Typical Dose: 100-300 mcg
Frequency: 2-3 times daily
Route: Subcutaneous injection
FDA Approved: No
View GHRP-6 Details
Key Differences
AspectIpamorelinGHRP-6
SelectivityHighly selective, minimal cortisol/prolactinLess selective, increases cortisol/prolactin
AppetiteMinimal effect on appetiteStrong appetite stimulation
GH ReleaseModerate, clean releaseStronger GH release
Side EffectsMild: headache, lightheadednessIntense hunger, water retention, cortisol
Dosing200-300 mcg 2-3x daily100-300 mcg 2-3x daily
When to Use Each

Ipamorelin May Be Better For:

  • Minimal side effects preferred
  • No appetite increase wanted
  • Cortisol increase a concern
  • Cleaner GH release profile

GHRP-6 May Be Better For:

  • Maximum GH release desired
  • Appetite stimulation beneficial (bulking)
  • Cost-conscious (often cheaper)
  • Gastroprotective effects needed

Both Are Good For:

GH optimizationAnti-aging protocolsRecovery enhancementSleep improvement
Side Effects Comparison

Ipamorelin

  • Headache
  • Lightheadedness
  • Injection site reaction

GHRP-6

  • Intense hunger
  • Water retention
  • Cortisol elevation
  • Fatigue
The Verdict

Ipamorelin is preferred for most users due to its cleaner profile and lack of appetite stimulation. GHRP-6 may be better for those wanting appetite increase (hardgainers) or maximum GH release regardless of side effects.

Research Data

Ipamorelin

20
Animal Studies
2
Human Studies

GHRP-6

40
Animal Studies
8
Human Studies
Dosing Tools
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Research Purposes Only

This comparison is for educational purposes. Consult a healthcare provider before using any peptides.