CalcPep Research
Comparison

CJC-1295 vs Sermorelin: Comparing Growth Hormone Secretagogues

Both are GHRH analogs that stimulate natural growth hormone production. Sermorelin is FDA-approved with shorter half-life (better for mimicking natural pulses), while CJC-1295 (especially with DAC) offers longer-lasting effects.

CJC-1295
Typical Dose: 100-300 mcg
Frequency: Once daily or 2-3 times weekly (with DAC)
Route: Subcutaneous injection
FDA Approved: No
View CJC-1295 Details
Sermorelin
Typical Dose: 200-500 mcg
Frequency: Once daily before bed
Route: Subcutaneous injection
FDA Approved: Yes
View Sermorelin Details
Key Differences
AspectCJC-1295Sermorelin
FDA StatusNot FDA-approvedFDA-approved (pediatric GHD)
Half-Life30 min (no DAC) or 6-8 days (with DAC)10-20 minutes
Dosing100-300 mcg daily or 2-3x weekly (DAC)200-500 mcg daily
GH PatternMore sustained elevationMimics natural pulsatile release
Research15 animal, 3 human studies30 animal, 20 human studies
When to Use Each

CJC-1295 May Be Better For:

  • Less frequent dosing preferred
  • Sustained GH elevation desired
  • Combined with GHRP protocols
  • Cost considerations (less frequent dosing)

Sermorelin May Be Better For:

  • FDA-approved option required
  • Natural GH pulse pattern preferred
  • Better sleep quality focus
  • Pediatric GH deficiency (approved use)

Both Are Good For:

Anti-aging protocolsBody composition improvementRecovery enhancementSleep quality improvement
Side Effects Comparison

CJC-1295

  • Water retention
  • Numbness/tingling
  • Fatigue
  • Headache

Sermorelin

  • Injection site pain
  • Flushing
  • Headache
  • Dizziness
The Verdict

Sermorelin better mimics natural GH release patterns and has FDA approval. CJC-1295 (especially with DAC) offers convenience with less frequent dosing. Both are often combined with GHRPs for synergistic effects.

Research Data

CJC-1295

15
Animal Studies
3
Human Studies

Sermorelin

30
Animal Studies
20
Human Studies
Dosing Tools
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Research Purposes Only

This comparison is for educational purposes. Consult a healthcare provider before using any peptides.